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Wednesday, February 29, 2012
Join us for Microsoft's Windows 8 press conference tomorrow at 9am EST!
If you're Microsoft and in the process of overhauling Windows so that it's equally at home on PCs and tablets, it would make sense to unveil a semi-final version at the world's premier wireless show. That's exactly what's going to happen tomorrow, when the company's executive team takes the stage here in Barcelona to show off all the changes it's made to Win8 since we got hands-on with the Developer Preview five months ago. Though we still won't know tomorrow what the final version will look like, we'll have a much firmer idea, as this will be the first version available to the general Windows-using populace. So what does Redmond have up its sleeve? Will the Windows Store open for business? A first look at some native touch-friendly apps? And what's to become of the Start button? Bookmark this page and come back tomorrow at 9am EST (3:30pm local time), when we'll be firing off up-to-the-minute updates. See you then!
February 29, 2012 9:00 AM EST
Join us for Microsoft's Windows 8 press conference tomorrow at 9am EST! originally appeared on Engadget on Tue, 28 Feb 2012 13:00:00 EDT. Please see our terms for use of feeds.
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Tuesday, February 28, 2012
Immortal worms defy ageing
ScienceDaily (Feb. 27, 2012) ? Researchers from The University of Nottingham have demonstrated how a species of flatworm overcomes the aging process to be potentially immortal.
The discovery, published in the Proceedings of the National Academy of Sciences, is part of a project funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) and may shed light on the possibilities of alleviating aging and age-related characteristics in human cells. Planarian worms have amazed scientists with their apparently limitless ability to regenerate. Researchers have been studying their ability to replace aged or damaged tissues and cells in a bid to understand the mechanisms underlying their longevity.
Dr Aziz Aboobaker from the University's School of Biology, said: "We've been studying two types of planarian worms; those that reproduce sexually, like us, and those that reproduce asexually, simply dividing in two. Both appear to regenerate indefinitely by growing new muscles, skin, guts and even entire brains over and over again.
"Usually when stem cells divide -- to heal wounds, or during reproduction or for growth -- they start to show signs of aging. This means that the stem cells are no longer able to divide and so become less able to replace exhausted specialised cells in the tissues of our bodies. Our aging skin is perhaps the most visible example of this effect. Planarian worms and their stem cells are somehow able to avoid the aging process and to keep their cells dividing."
One of the events associated with aging cells is related to telomere length. In order to grow and function normally, cells in our bodies must keep dividing to replace cells that are worn out or damaged. During this division process, copies of the genetic material must pass on to the next generation of cells. The genetic information inside cells is arranged in twisted strands of DNA called chromosomes. At the end of these strands is a protective 'cap' called a telomere. Telomeres have been likened to the protective end of a shoelace which stops strands from fraying or sticking to other strands.
Each time a cell divides the protective telomere 'cap' gets shorter. When they get too short, the cell loses its ability to renew and divide. In an immortal animal we would therefore expect cells to be able to maintain telomere length indefinitely so that they can continue to replicate. Dr Aboobaker predicted that planarian worms actively maintain the ends of their chromosomes in adult stem cells, leading to theoretical immortality.
Dr Thomas Tan made some exciting discoveries for this paper as part of his PhD. He performed a series of challenging experiments to explain the worm's immortality. In collaboration with the rest of the team, he also went some way to understanding the clever molecular trick that enabled cells to go on dividing indefinitely without suffering from shortened chromosome ends.
Previous work, leading to the award of the 2009 Nobel Prize for Physiology or Medicine, had shown that telomeres could be maintained by the activity of an enzyme called telomerase. In most sexually reproducing organisms the enzyme is most active only during early development. So as we age, telomeres start to reduce in length.
This project identified a possible planarian version of the gene coding for this enzyme and turned down its activity. This resulted in reduced telomere length and proved it was the right gene. They were then able to confidently measure its activity and resulting telomere length and found that asexual worms dramatically increase the activity of this gene when they regenerate, allowing stem cells to maintain their telomeres as they divide to replace missing tissues.
Dr Tan pointed out the importance of the interdisciplinary expertise: "It was serendipitous to be sandwiched between Professor Edward Louis's yeast genetics lab and the Children's Brain Tumour Research Centre, both University of Nottingham research centres with expertise in telomere biology. Aziz and Ed kept demanding clearer proof and I feel we have been able to give a very satisfying answer."
However, what puzzled the team is that sexually reproducing planarian worms do not appear to maintain telomere length in the same way. The difference they observed between asexual and sexual animals was surprising, given that they both appear to have an indefinite regenerative capacity. The team believe that sexually reproductive worms will eventually show effects of telomere shortening, or that they are able to use another mechanism to maintain telomeres that would not involve the telomerase enzyme.
Dr Aboobaker concluded: "Asexual planarian worms demonstrate the potential to maintain telomere length during regeneration. Our data satisfy one of the predictions about what it would take for an animal to be potentially immortal and that it is possible for this scenario to evolve. The next goals for us are to understand the mechanisms in more detail and to understand more about how you evolve an immortal animal."
Professor Douglas Kell, BBSRC Chief Executive, said: "This exciting research contributes significantly to our fundamental understanding of some of the processes involved in aging, and builds strong foundations for improving health and potentially longevity in other organisms, including humans."
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The above story is reprinted from materials provided by University of Nottingham, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Thomas C. J. Tan, Ruman Rahman, Farah Jaber-Hijazi, Daniel A. Felix, Chen Chen, Edward J. Louis, and Aziz Aboobaker. Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms. Proceedings of the National Academy of Sciences, February 27, 2012 DOI: 10.1073/pnas.1118885109
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/02/120227152612.htm
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Fight Arthritis With These Simple Tips And Tricks | New Health and ...
New Health And Fitness.Org - Health Information You Can Use
If you have arthritis or know someone who has been diagnosed with it, you are aware that it is a painful and challenging condition to deal with. Treating arthritis, however, is easier if you know what to do. This article has tips on how you can deal with your arthritis symptoms.
Rhematoid arthritis is not a death sentence. Go about your daily life and activities the best that you can. Although these activities may bring on arthritis flare ups, see if there is a way that you can modify them instead of giving up on them completely. Look for less stressful ways to sew or cook, or do anything that you enjoy.
Keep a diary about your arthritis and how it is affecting your daily life. Documenting your flare-ups in a daily journal may make it easier to identify possible triggers. It also lets you pinpoint useful strategies. Your doctor can use this information to decide which treatment would be best for you. A diary can obviously be a very helpful, valuable resource.
Keep an eye out for new and current types of treatment. However, most of the time, a doctor will not try a new treatment unless the old one is not working at all. However, if you hear of a new treatment that you feel is better suited to you, then it is up to you to discuss it with your doctor and see how they feel about moving over to the new plan.
There are many different treatments for arthritis joint inflammation. There are many different folk remedies that have been effective with some people for treating their arthritis. Try searching for folk remedies to help with your arthritis symptoms. Since it is completely natural, it is well worth trying urtication as a form of relief for the daily pain of your arthritis.
If you suffer from psoriatic arthritis, do not try to do everything. Remember that you don?t have the same amount of energy as you used to. By not paying attention to what your body is telling you, you will only make the symptoms worse. Put all your energy towards the stuff that is important to you. Focus on what is important to you, and do not waste your time trying to fulfill all the roles people are expecting you to.
Be on the lookout for the development of new treatments. However, most of the time, a doctor will not try a new treatment unless the old one is not working at all. Remember that you have the final say over the treatment of your body, so don?t hesitate to bring up new treatments you are interested in trying with your doctor.
Always be attuned to your body?s signals. Everyone who has arthritis symptoms is different, so you are the one who can truly tell how your arthritis feels. Pay attention to any signals your body may be sending out, and heed them. If you feel the need to take a rest, take one.
Eat a lot of protein. Though you may be unaware of it, protein is consumed more heavily by those with arthritic conditions. If you?re vegetarian, you need to find healthy protein sources to eat regularly so that you can fight inflammation and pain.
When it comes to arthritis pain, there is no cause for concern about taking any medications that your physician has prescribed to help alleviate the pain. Prescription medicines are tested to be safe in the amounts prescribed, and your doctor gave them to you to help you reduce your arthritis pain and symptoms.
Drink lots of water. While you may want something else, water is the most healthy fluid for you. You should reach for it anytime you feel thirst. Avoid beverages with caffeine, which is dehydrating.
If you want your joint pain to improve, work on your abdominal muscles. Strong back and abdominal muscles help you carry the weight of your body properly. Know your limitations and avoid overdoing it with your workouts.
While rheumatoid arthritis is a serious condition, it helps if you can learn to laugh. Countless studies show that laughter will improve overall mood and reduce the stress brought on by arthritis. Take a break, watch some comedy on TV, or anything else that makes laugh in order to put a smile on your face.
Just because you may have been diagnosed with an arthritic condition does not mean you need to forgo the things in life you love doing. It is possible that these things would cause a flare up though, so find ways to tailor them to your new condition. There are low stressful ways to do practically anything.
If you have arthritis, try to optimize your sleep during the night. Lack of sleep makes it impossible for the body to fight painful arthritis effects. Adults need an average of eight hours of sleep, but more may be necessary when you are stressed. Your body?s own healing powers improve substantially with good sleep.
To get temporary relief, invest in a heating pad with moist heat. A quality moist heating pad is a great investment for those times when the pain of arthritis is especially nagging. They won?t remove your pain completely, so it is essential to stay in touch with a doctor.
You may want to speak with a occupational therapist. A good occupational therapist will teach you to live independently and target areas that are impacting your life. When you learn these kind of tricks from your OT you can then focus more on living life free from pain.
People who suffer with arthritis in their knees should consider using a knee brace prior to thinking about having surgery. Knee braces are quite effective at reducing swelling, inflammation and pain caused by arthritis. Having knee surgery should only be considered after all other options have failed. You can even try using one as you sleep.
Keep your joints protected. Overexertion with arthritis is going to worsen the pain, so it?s very important that arthritis sufferers take it easy with their day-to-day tasks.
This may not be a cure for arthritis, but these simple daily changes can result in stopping some of the common causes for the issue. Many people develop the problem because of everyday things, such as posture or the way they walk. With this article, you can begin to change these activities into something that can, instead, shield your joints from a lifetime of pain.
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Source: http://newhealthandfitness.org/2012/02/27/fight-arthritis-with-these-simple-tips-and-tricks-2/
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Future of Online Games | Boss Attack!
Online Games ?r? games played over ??m? form ?f computer network. Online games range fr?m simple text based games t? games incorporating complex graphics ?nd virtual worlds populated b? many players simultaneously. It includes games l?k? casino, poker, sports, shooting games, risk ?nd adventure games, ?nd many more. Many outsourced software development companies ?r? now ?nt? games development. Online gaming itself h?? developed ?? full-fledged business. Th?r? ?r? various software development tools such ?? 3D flash animator, flash, th?t ?r? widely used b? game development companies.
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Online games h??? more advanced features th?n ???r standalone non-internet games. Th? competition ?n online games ?? ?l?? a driving force f?r th??r popularity. Online games allow players t? challenge themselves more. O?r busy life m?k?? playing w?th a group ?f friends difficult. Online games solve th?? problem b? allowing busy people t? hop online ?nd play ?? ?nd wh?n th?? want. Many online games h??? associated online communities ?? well ?? communities providing software development services?, a form ?f social activity beyond single player games.
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Online gaming h?? continued t? increase ?n popularity. S? much th?t th? income generated fr?m games ?? greater th?n th? income earned b? Hollywood. Th? future ?f online game?s design & development ?? clear ?nd unquestionable w?th venturing ?f game development companies ?nt? online console gaming, Xbox Online, PlayStation 2 ?nd rapidly expanding mobile gaming market. Offshore product development companies ?r? developing widely used gaming products. Th? online games h??? brought th? adventure ?nd enthusiasm down t? ??r desktops.
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Online gaming ?? a n?w phase ?f software product development ?n th? modern world. It ?? a means ?f connecting people together. Th? increase ?n popularity ?f online gaming h?? resulted ?n increase ?f overall expansion ?f computer networks ?nd increase t? th? growth ?f th? internet access ?nd activities. More ?nd more companies w?ll b? seeking out advertising ?n online games ?? a way t? expand ?nd grow th??r business ?nd reach a targeted audience. Game owners collect ?m??rt?nt demographic data ?n th??r players, wh??h yield t? targeted advertising ?nd more value f?r th??r money. Th? Internet offers gr??t diversity ?f games nowadays.
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Online gaming h?? now become very ????l?r ?n people ?f ?ll ages ?ll ??r??? th? world. Many games associate w?th themselves a very n?w concept ?f online gaming. W? ??n h??? number ?f gaming zones, several gaming communities, multiplayer online games, ?nd ?l?? online game governance laws.
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A? w? ?ll ?r? aware th?t today, th? Internet ?? serving ?? th? living organism hosting many online systems. It h?? overcome ?ll th? issues whether ?t ?? related t? geographical boundaries ?f th? world, economy, educational ?r cultural ?nd family traditions. Communities ?r? being established f?r social interaction. Gamers ??n send messages t? ?th?r gamers, th?? ??n ?l?? exchange email addresses freely ?nd interact w?th th? game community. Communities ?r? undoubtedly becoming ?n extension ?nd serving ?? a n?w medium ?f human touch. Gamers ?r? now th? co-authors th?t ?r? authorized t? take ??rt ?n th? experience.
Nick Thomas ?? th? author ?f th?? article. H? h?? b??n writing articles f?r software product development companies l?k? Q3 technologies ??n?? last three years. H? ?l?? h?? a k??n interest ?n software development services. ?F?r more details, feel free t? visit http://www.q3tech.com
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